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KMID : 0358419950380071253
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Korean Journal of Obstetrics and Gynecology
1995 Volume.38 No. 7 p.1253 ~ p.1258
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The Effect of Postmenopausal Hormone Replacement Therapy on Serum Lipoprotein (a) Concentration
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조은정
이병석/정창진/임영구/차동현/박기현/조동제/이국/송찬호
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Abstract
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Objectives :
@EN To evaluate whether postmenopausal hormone replacement therapy influences the plasma lipoproteins with special emphasis on lipoprotein [a].
@ES Methods:
@EN 60 postmenopausal women, who visited Yongdong severance hospital were assesed. After a baseline study, conjugated equine estrogen(0.625mg) was given to 12 women(group A) and conjugated equine estrogen(0.625mg) plus medroxyprogesterone acetate
(5 mg)
were given to 48 women(group B). Blood samples were obtained at 3 months and 5 months after therapy.
@ES Results:
@EN Serum lipoprotein [a] concentration was not correlated with the age and the duration of menopause. Serum total cholesterol was decreased from 216.0±13.8mg/dl to 198.5±6.9/dl at 5 months after therapy(p<0.05). Serum LDL was decreased from
146.8±6.6mg/dl to 120.9±8.4mg/dl and serum HDL was increased from 46.4±2.6mg/dl to 50.0±2.5mg/dl, but did not statisticaly significant. Serum lipoprotein a was decreased in 52.6% at 5 months after therapy(P<0.01) and there was no difference
between
3 two groups (53.7% in group A, 49.6% in group B).
@ES Conclusion:
@EN Postmenopausal hormone replacement therapy improve the lipid profiles including lipoprotein [a], and this change may be the mechanism of the cardioprotective effect of hormone replacement therapy.
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KEYWORD
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